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Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Mole­cu­lar and Cel­lu­lar Bio­en­gi­nee­ring (CMCB), Bio­tech­no­logy Cen­ter (BIO­TEC), Rese­arch Group Bio­me­di­cal Geno­mics

Tech­ni­sche Uni­ver­si­tät Dres­den (TUD), as a Uni­ver­sity of Excel­lence, is one of the lea­ding and most dyna­mic rese­arch insti­tu­ti­ons in the coun­try. Foun­ded in 1828, today it is a glo­bally ori­en­ted, regio­nally ancho­red top uni­ver­sity as it focu­ses on the grand chal­len­ges of the 21st cen­tury. lt deve­lops inno­va­tive solu­ti­ons for the world's most pres­sing issues. In rese­arch and aca­de­mic pro­grams, the uni­ver­sity unites the natu­ral and engi­nee­ring sci­en­ces with the huma­nities, social sci­en­ces and medi­cine. This wide range of disci­pli­nes is a spe­cial fea­ture, faci­li­ta­ting inter­di­sci­pli­na­rity and trans­fer of sci­ence to society. As a modern employer, it offers attrac­tive working con­di­ti­ons to all employees in tea­ching, rese­arch, tech­no­logy and admi­nis­tra­tion. The goal is to pro­mote and deve­lop their indi­vi­dual abi­li­ties while empowering ever­yone to reach their full poten­tial. TUD embo­dies a uni­ver­sity cul­ture that is cha­rac­te­ri­zed by cos­mo­po­li­ta­nism, mutual appre­cia­tion, thri­ving inno­va­tion and active par­ti­ci­pa­tion.

For TUD diver­sity is an essen­tial fea­ture and a qua­lity cri­ter­ion of an excel­lent uni­ver­sity. Accord­in­gly, we wel­come all app­li­cants who would like to com­mit them­sel­ves, their achie­ve­ments and pro­duc­tivity to the suc­cess of the whole insti­tu­tion.

Rese­arch Asso­ciate/Post­doc Com­pu­ta­tio­nal Can­cer Bio­logy (m/f/x)

English

(sub­ject to per­so­nal qua­li­fi­ca­tion employees are remu­ne­ra­ted accord­ing to salary group E 13 TV-L)

The posi­tion is star­ting on April 1, 2023 or as soon as pos­si­ble. The posi­tion is limi­ted for 2 years. An exten­sion to appro­xi­mately 4 years is anti­ci­pa­ted. The period of employ­ment is gover­ned by the Fixed Term Rese­arch Con­tracts Act (Wis­sen­schafts­zeit­ver­trags­ge­setz-WissZeitVG). The posi­tion offers the chance to obtain fur­ther aca­de­mic qua­li­fi­ca­tion.

Working field:

Tumours deve­lop by step­wise acqui­si­tion of abnor­mal cel­lu­lar beha­viour through gene­tic and non-gene­tic chan­ges. In the evol­ving pro­cess they accu­mu­late hete­ro­gen­eity, a main dri­ver for the­rapy resis­tance and rel­apse.
To streng­t­hen our diverse team, we are loo­king for a post­doc­to­ral fel­low to study tumour evo­lu­tion, hete­ro­gen­eity, and resis­tance in fusion-gene-dri­ven sar­co­mas in child­ren and young adults. This is part of a large „Decade Against Can­cer“ con­sor­tium „HEROES-AYA“ dis­tri­bu­ted over mul­ti­ple loca­ti­ons, inclu­ding the Ger­man Can­cer Rese­arch Cen­ter (dkfz).
The Rese­arch Group of Anna Poe­tsch, where this pro­ject will be based, will par­ti­cu­larly focus on data inte­gra­tion of lar­gely multi-omics data in bulk and sin­gle cell to gene­rate bio­lo­gi­cal insight into mecha­nisms behind tumour evo­lu­tion, hete­ro­gen­eity, and resis­tance.
The posi­tion will offer an exci­ting col­la­bo­ra­tive inter­di­sci­pli­nary rese­arch pro­ject embed­ded in a pres­ti­gious rese­arch con­sor­tium. The suc­cess­ful can­di­date will use methods on multi-omics data ana­ly­sis and machine lear­ning to inves­ti­gate bio­lo­gi­cal mecha­nisms behind tumour evo­lu­tion, hete­ro­gen­eity, and resis­tance. Data will be avail­able for geno­mics (WGS, sc-DNA-seq, spa­tial geno­mics, copy num­ber alte­ra­ti­ons), epi­ge­no­mics (ATAC-Seq, sc-ATAC-Seq, DNA methyla­tion), tran­scrip­to­mics (RNA-Seq, scRNA-Seq), pro­teo­mics, patho­logy, radio­logy, liquid biop­sies, cli­ni­cal data, and expe­ri­men­tal data on pati­ent-matching orga­noid models. Thus, the suc­cess­ful can­di­date will have the oppor­tu­nity to receive trai­ning in cut­ting edge methods in multi-omics data inte­gra­tion (in bulk and sin­gle cell), state-of-the-art and novel machine lear­ning approa­ches, and trans­la­tio­nal can­cer rese­arch. This also app­lies to tea­ching (e.g. by super­vi­sing tuto­ri­als) and sci­en­ti­fic work.

Requirements:

  • excel­lent uni­ver­sity and PhD degree with expe­ri­ence in at least one of mole­cu­lar bio­logy, com­pu­ta­tio­nal bio­logy, gene­tics, geno­mics, can­cer bio­logy, or equi­va­lent sci­en­ti­fic back­ground with an excel­lent under­stan­ding of genome bio­logy and can­cer rese­arch.
  • Com­pre­hen­sive pro­gramming expe­ri­ence in python and/or R.
  • Demons­tra­ble expe­ri­ence in multi-omics data ana­ly­sis.
  • very good inter­per­so­nal and com­mu­ni­ca­tion skills; in par­ti­cu­lar, the abi­lity to effec­tively work in a diverse, col­la­bo­ra­tive and inter­di­sci­pli­nary rese­arch envi­ron­ment.
  • Flu­ency in Eng­lish - writ­ten and oral. (Ger­man is not requi­red).

What we offer:

The BIO­TEC/CMCB is a renow­ned inter­di­sci­pli­nary and inter­na­tio­nal rese­arch insti­tute of the TU Dres­den that boasts a col­la­bo­ra­tive spi­rit and cut­ting-edge tech­no­logy plat­forms, inclu­ding one of the natio­nal genome cen­tres and cut­ting-edge High Per­for­mance Com­pu­ting resour­ces. The city of Dres­den and the HEROES-AYA con­sor­tium pro­vide nume­rous chan­ces for sci­en­ti­fic exchange and col­la­bo­ra­tion.
TUD stri­ves to employ more women in aca­de­mia and rese­arch. We the­re­fore expressly encou­rage women to apply. The Uni­ver­sity is a cer­ti­fied family-fri­endly uni­ver­sity and offers a Dual Career Ser­vice. We wel­come app­li­ca­ti­ons from can­di­da­tes with disa­bi­li­ties. If mul­ti­ple can­di­da­tes prove to be equally qua­li­fied, those with disa­bi­li­ties or with equi­va­lent sta­tus pur­suant to the Ger­man Social Code IX (SGB IX) will receive prio­rity for employ­ment.

How to apply:

Please sub­mit your com­pre­hen­sive app­li­ca­tion inclu­ding the usual docu­ments, inclu­ding a let­ter of moti­va­tion, your CV inclu­ding a list of publi­ca­ti­ons, tran­scripts of records, and con­tact details for 2-3 aca­de­mic refe­ren­ces, by Janu­ary 31, 2023 (stam­ped arri­val date of the uni­ver­sity cen­tral mail ser­vice app­lies) pre­fer­a­bly via the TU Dres­den Secu­re­Mail Por­tal https://securemail.tu-dresden.de by sen­ding it as a sin­gle pdf docu­ment to sabine.zeissig@tu-dresden.de, alter­na­tively via mail to: TU Dres­den, BIO­TEC, For­schungs­gruppe Bio­me­di­zi­ni­sche Geno­mik, Frau Dr. Anna Poe­tsch, Helm­holtz­str. 10, 01069 Dres­den, Ger­many. Please sub­mit copies only, as your app­li­ca­tion will not be retur­ned to you. Expen­ses incur­red in atten­ding inter­views can­not be reim­bur­sed.

Refe­rence to data pro­tec­tion: Your data pro­tec­tion rights, the pur­pose for which your data will be pro­ces­sed, as well as fur­ther infor­ma­tion about data pro­tec­tion is avail­able to you on the web­site: https://tu-dresden.de/karriere/datenschutzhinweis.