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Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Mole­cu­lar and Cel­lu­lar Bio­en­gi­nee­ring (CMCB), Bio­tech­no­logy Cen­ter (BIO­TEC), Rese­arch Group Bio­me­di­cal Geno­mics

The Bio­tech­no­logy Cen­ter (BIOTEC) (https://tu-dresden.de/cmcb/biotec) and its part­ner insti­tu­tions, B CUBE and the Cen­ter for Regen­er­at­ive Ther­apies (CRTD), are equipped with state-of-the-art facil­it­ies for Molecu­lar Bios­cience research (https://tu-dresden.de/cmcb/bcube/forschung-technologie/technologieplattform). They are part of a rich and col­lab­or­at­ive envir­on­ment that includes the Fac­ulty of Math­em­at­ics and Nat­ural Sci­ences, the Fac­ulty of Medi­cine, the Max-Planck- Insti­tute of Molecu­lar Cell Bio­logy and Genet­ics (MPI-CBG), and the Leib­niz Insti­tute for Poly­mer Research (IPF). For TUD diversity is an essen­tial fea­ture and a qual­ity cri­terion of an excel­lent uni­versity. Accord­ingly, we wel­come all applic­ants who would like to com­mit them­selves, their achieve­ments and pro­ductiv­ity to the suc­cess of the whole insti­tu­tion. For TUD diversity is an essen­tial fea­ture and a qual­ity cri­terion of an excel­lent uni­versity. Accord­ingly, we wel­come all applic­ants who would like to com­mit them­selves, their achieve­ments and pro­ductiv­ity to the suc­cess of the whole insti­tu­tion.

Rese­arch Asso­ciate / Post­doc Com­pu­ta­tio­nal Genome Bio­logy (m/f/x)

English

(sub­ject to per­sonal qual­i­fic­a­tion employ­ees are remu­ner­ated accord­ing to salary group E 13 TV-L)

The pos­i­tion is start­ing as soon as pos­sible. The pos­i­tion with 100% of the full­time weekly hours is lim­ited for 2 years. An exten­sion to approx­im­ately 4 years is anti­cip­ated. The period of employ­ment is gov­erned by the Fixed Term Research Con­tracts Act (Wis­senschaft­szeitver­trags­ge­setz-Wis­sZeitVG). The pos­i­tion offers the chance to obtain fur­ther aca­demic qual­i­fic­a­tion.

Working field:

3D genome archi­tec­ture plays a major role in genome orga­ni­sa­tion, gene regu­la­tion and genome sta­bi­lity. Thus, dere­gu­la­tion of 3D genome archi­tec­ture is also an important mecha­nism con­tri­bu­ting to disease.
To streng­t­hen our diverse team, we are loo­king for a post­doc­to­ral fel­low to study genome archi­tec­ture as part of the DFG prio­rity pro­gram „Spa­tial Genome Archi­tec­ture in Deve­lop­ment and Disease (Genome3)“. We will par­ti­cu­larly focus on the nuclear pore and how it affects gene regu­la­tion and genome sta­bi­lity in neural deve­lop­ment and brain can­cer. The pro­ject is a col­la­bo­ra­tion bet­ween the lab of Tomo­hisa Toda on „Nuclear archi­tec­ture in neural plasti­city and age­ing“ and the com­pu­ta­tio­nal Rese­arch Group of Anna Poe­tsch on „Bio­me­di­cal Geno­mics“ at the Bio­tech­no­logy Cen­ter of the TU Dres­den, where this posi­tion will be based.
The posi­tion will offer an exci­ting col­la­bo­ra­tive inter­di­sci­pli­nary rese­arch pro­ject embed­ded in a pres­ti­gious rese­arch pro­gram. The suc­cess­ful can­di­date will use methods on multi-omics data ana­ly­sis to inves­ti­gate how 3D genome archi­tec­ture in the nuclear pore affects gene regu­la­tion and genome sta­bi­lity with data on genome archi­tec­ture (e.g. HiC, Hi-ChiP, DamID-HiChiP, MicroC), gene regu­la­tion (e.g. ChiP, DamID-ChiP, ATAC-Seq, RNA-seq), DNA damage (AP-Seq, 8-oxoG, END-Seq), germline muta­ti­ons in neu­ro­de­ve­lop­men­tal dis­or­ders, and soma­tic muta­ti­ons in paediatric brain tumours. Thus, the suc­cess­ful can­di­date will have the oppor­tu­nity to receive trai­ning in cut­ting-edge methods in multi-omics data inte­gra­tion and the pos­si­bi­lity to learn and apply machine lear­ning and deep lear­ning methods on geno­mics data.

Requirements:

  • Excel­lent uni­ver­sity and PhD degree with expe­ri­ence in mole­cu­lar bio­logy, com­pu­ta­tio­nal bio­logy, gene­tics, geno­mics, or equi­va­lent sci­en­ti­fic back­ground with an excel­lent under­stan­ding of genome bio­logy.
  • Com­pre­hen­sive pro­gramming expe­ri­ence in python and/or R.
  • Demons­tra­ble expe­ri­ence in multi-omics data ana­ly­sis.
  • Very good inter­per­so­nal and com­mu­ni­ca­tion skills; in par­ti­cu­lar, the abi­lity to effec­tively work in a diverse, col­la­bo­ra­tive and inter­di­sci­pli­nary rese­arch envi­ron­ment.
  • Flu­ency in Eng­lish - writ­ten and oral. (Ger­man is not requi­red).

What we offer:

The BIO­TEC/CMCB is a renow­ned inter­di­sci­pli­nary and inter­na­tio­nal rese­arch insti­tute of the TU Dres­den that boasts a col­la­bo­ra­tive spi­rit and cut­ting-edge tech­no­logy plat­forms, inclu­ding one of the natio­nal genome cen­tres and cut­ting-edge High Per­for­mance Com­pu­ting resour­ces. The city of Dres­den and the DFG focus pro­gram (Genome3) pro­vide nume­rous oppor­tu­nities for sci­en­ti­fic exchange and col­la­bo­ra­tion.

How to apply:

TUD strives to employ more women in aca­demia and research. We there­fore expressly encour­age women to apply. The Uni­versity is a cer­ti­fied fam­ily-friendly uni­versity and offers a Dual Career Ser­vice. We wel­come applic­a­tions from can­did­ates with dis­ab­il­it­ies. If mul­tiple can­did­ates prove to be equally qual­i­fied, those with dis­ab­il­it­ies or with equi­val­ent status pur­su­ant to the Ger­man Social Code IX (SGB IX) will receive pri­or­ity for employ­ment.
Please sub­mit your com­pre­hens­ive applic­a­tion includ­ing the usual doc­u­ments, includ­ing a let­ter of motiv­a­tion, your CV includ­ing a list of pub­lic­a­tions, tran­scripts of records, and con­tact details for 2-3 aca­demic ref­er­ences, by Janu­ary 31, 2023 stamped arrival date of the uni­versity cent­ral mail ser­vice applies) prefer­ably via the TU Dresden Secure­Mail Portal https://securemail.tu-dresden.de by send­ing it as a single pdf doc­u­ment to sabine.zeissig@tu-dresden.de, altern­at­ively via mail to: TU Dresden, BIOTEC, Forschungs­gruppe Bio­med­iz­in­is­che Gen­omik, Frau Dr. Anna Poetsch, Helm­holtz­str. 10, 01069 Dresden, Ger­many. Please sub­mit cop­ies only, as your applic­a­tion will not be returned to you. Expenses incurred in attend­ing inter­views can­not be reim­bursed.

Ref­er­ence to data pro­tec­tion: Your data pro­tec­tion rights, the pur­pose for which your data will be pro­cessed, as well as fur­ther inform­a­tion about data pro­tec­tion is avail­able to you on the web­site: https://tu-dresden.de/karriere/datenschutzhinweis.